Thirteen State Senate races contested
- 1st District Sen. Ken Winters, R-Murray, will face the winner of a Democratic Primary between Carroll Hubbard (former congressman) and Rick Johnson (former Appeals Court Judge).
- 3rd District: Sen. Joey Pendleton, D-Hopkinsville, versus Republican challenger Tom Jones, a Christian County magistrate.
- 5th District: Sen. Carroll Gibson, R-Leitchfield, versus Democratic challenger Barry Cannon of Caneyville — a rematch of the 2004 race that Gibson won.
- 7th District: Sen. Julian Carroll, D-Frankfort, UNOPPOSED
- 9th District OPEN SEAT Democratic Primary: Steve Newberry (broadcaster, businessman), John Rogers (Glasgow lawyer) and Horace F. Johnson (former law enforcement official). Republican Primary: Jeffery Jobe (newspaper publisher), David P. Givens of Greensburg and Bob Bryant of Glasgow.
- 11th District OPEN SEAT Republican Primary: Charlie Walton (former principal and former state Rep.) versus John Schickel (former U.S. Marshal)
- 13th District: Sen. Ernesto Scorsone, D-Lexington, UNOPPOSED
- 15th District: Sen. Vernie McGaha, R-Russell Springs, UNOPPOSED
- 17th District: Sen. Damon Thayer, R-Georgetown, will face the winner of the Democratic Primary between Rand L. Marshall (assistant Scott County attorney) and Robert Powell of Georgetown.
- 19th District: Sen. Tim Shaughnessy, D-Louisville, versus Republican Bob Heleringer, a lawyer and former state representative
- 21st District: Sen. Tom Jensen, R-London, UNOPPOSED
- 23rd District: Sen. Jack Westwood, R-Crescent Springs, versus Democrat Kathy Groob of Covington, a rematch of the 2004 race that Westwood won.
- 25th District: Sen. Robert Stivers, R-Manchester, will take on the winner of the Democratic Primary between Michael “Whitey” Adkins of West Liberty and Pete M. Frye of Campton.
- 27th District: Sen. Walter “Doc” Blevins, D-Sandy Hook, versus Republican Richard White of Morehead.
- 29th District Sen. Johnny Ray Turner, D-Drift, faces a Democratic primary challenge from Eric Shane Hamilton – a rematch of the 2004 primary election that Turner won by 24 votes.
- 31st District: Sen. Ray Jones, D-Pikeville, UNOPPOSED
- 33rd District Sen. Gerald Neal, D-Louisville, faces a Democratic primary challenge from Marshall “Marty” Gazaway of Louisville.
- 35th District: Sen. Denise Harper Angel, D-Louisville, versus Republican John Albers of Louisville
- 37th District: Sen. Perry Clark, D-Louisville, versus Republican Doug Hawkins (a Louisville metro councilman